The pioneer of anticancer drugs: cisplatin
WebbAbstract: This review provides a brief view of the cisplatin's mechanism of action, toxicity … The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli (E. coli) bacteria. Although bacterial cell growth continued, cell division …
The pioneer of anticancer drugs: cisplatin
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Webb1 mars 2024 · New strategies and formulations are being explored in the design of … WebbThe discovery of cis-platin was serendipitous. In 1965, Rosenberg was looking into the …
WebbEncapsulation of cisplatin in long-circulating and pH-sensitive liposomes improves its … Webb15 juni 2010 · Uptake of the anticancer drug cisplatin is mediated by the copper transporter CTR1 in cultured cells. Here we show in human ovarian tumors that low levels of Ctr1 mRNA are associated with poor clinical response to platinum-based therapy. Using a mouse model of human cervical cancer, we demonstrate t …
Webb10 apr. 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms … WebbCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is …
Webb1 juli 2024 · Abstract. Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its ...
Webb7 feb. 2024 · Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, such as lack of selectivity, high systemic toxicity, and drug resistance, seriously limit their clinical application. With advancements in nanotechnology and chemical synthesis, Pt ... d w winters livestockWebb1 jan. 2024 · Cisplatin was absorbed more readily than carboplatin, both in vitro and in … dw wlan utilityWebbFollowing its approval as second-line monotherapy for locally advanced or metastatic non-squamous NSCLC, pemetrexed has established itself as the first-line regimen in combination with cisplatin, and its powerful antitumor effects and less cumulative toxicities were then taken advantage of in the JMEN and PARAMOUNT trials, … dwwin.exe application crash dumpWebb9 mars 2024 · The dysregulation of apoptosis and DNA damage repair are two leading … dwwnv jhf llcWebbProject design, analysis, and regulation of in vitro and in vivo research for cancer targeting, mechanism of action, bio distribution, dosing regimens, and tumor efficacy prepared for FDA... dwwm reacWebb10 mars 2015 · The history of cisplatin starts not in 1965, but in 1844, when it was first … dww motorsports ayer maWebbThe rediscovery of platinum-based cancer therapy Platinum (Pt) compounds entered the … dww live