Rifm report on linalool

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August undefined, 2024

WebJan 28, 2015 · The use of linalool as an ingredient, according to the OECD report (CAS Number 78-70-6 2002), suggested that the compound has an LD50 following a cutaneous administration of 2000 mg/kg of body ... WebThe developmental toxicity of linalool, a widely used fragrance ingredient, was evaluated in presumed pregnant Sprague-Dawley rats (25/group). Oral dosages of 0, 250, 500, or 1000 mg/kg/day linalool were administered by gavage on gestational days 7 to 17. The presence of spermatozoa and/or a copulat …

RIFM fragrance ingredient safety assessment, l-linalool, CAS …

WebJan 28, 2015 · Linalool (C10H18O) is a monoterpenoid found in plant essential oils. It has a molecular weight of 154.25 and has properties that are less soluble in water because of … WebNov 1, 2016 · Six studies are reported in the RIFM Database for Linalool (CAS # 78-70-6). A study was conducted following OECD Guideline 302B. 722 mg/L of the test substance … how to reset a dial lock

Does RIFM study natural fragrance ingredients? - RIFM

Webtoxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and ... RIFM's Expert Panel* concludes that this material is safe under the limits described in this safety assessment. This safety assessment is based on the RIFM Criteria Document (Api et al., 2015) which should be referred to for ... WebJan 28, 2015 · RIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6. ... Linalool, CAS registry number 78-70-6. Api AM 1, Belsito D 2, Bhatia S 1, Bruze M 3, Calow P 4, Dagli ML 5, Dekant W 6, Fryer AD 7, Kromidas L 1, La Cava S 1, Lalko JF 1, Lapczynski A 1, ... WebOct 11, 2005 · Linalool is used in the food industry as a flavor ingredient. It has been recognized as GRAS ... Report to RIFM, 14 September. Prepared by Philip Morris USA, Inc.: October 11, 2005 Page 4 of 5 15. Hodge, H.C. and Sterner, J.H. (1949) Tabulation of toxicity classes. American Industrial Hygiene Association Quarterly 10:93-96. how to reset adderall tolerance

Safety Assessment The Research Institute for Fragrance …

RIFM fragrance ingredient safety assessment, Linalool, CAS …

Web9 Member RIFM Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, ... The developmental and reproductive toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8), benzoic acid (CAS # 65-85-0) and sodium benzoate (CAS # 532-32-1) as … WebRIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6. Food Chem Toxicol. 2015 Aug;82 Suppl:S29-38. doi: 10.1016/j.fct.2015.01.005. Epub 2015 Jan … north carolina hummingbird speciesWebMar 1, 2008 · In a 90-day dermal study, linalool was applied topically to Sprague-Dawley rats at doses of 250, 1000, or 4000 mg/kg/day. Dermal erythema was noted at all dose levels. At 250 mg/kg/day, there were no systemic changes observed ( Letizia et al. 2003; RIFM 1980 ). how to reset a dial safe

"WebNov 1, 2016 · Chemical Name: l-Linalool 2. CAS Registry Number: 126-91-0 3. Synonyms: (R)-3,7-Dimethyl-1,6-octadien-3-ol, l-Linalool, 1,6-Octadien-3-ol, 3,7-dimethyl-, (R)-, , 3,7 … " - Rifm report on linalool

Rifm report on linalool

Webb. Repeated Dose Toxicity: Linalool(CAS#78-70-6) c. Developmental and Reproductive Toxicity: Linalool(CAS# 78-70-6);dehydrolinalool(CAS#29171-20-8) d. Skin Sensitization: … WebThe developmental toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and cinnamic acid (CAS # 621-82-9) as suitable read across analogs, which provided a MOE > 100. The repeated dose toxicity endpoint was completed using data on the target material which provided a MOE > 100.

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WebNov 1, 2016 · l-Linalool safety assessment based on RIFM's criteria. • Safety assessment based on 7 Human health endpoints plus environmental. • Repeated dose toxicity was determined to have the most conservative NO [A]EL. • An acceptable MOE was obtained. Abstract The use of this material under current use conditions is supported by the existing … WebApi, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., … Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, Linalool, CAS registry ...

WebNov 1, 2024 · Request PDF On Nov 1, 2024, A.M. Api and others published RIFM fragrance ingredient safety assessment, linalool, CAS Registry number 78-70-6 Find, read and cite all the research you need on ... WebRIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6. / Api, A. M.; Belsito, D.; Bhatia, S. et al. In: Food and Chemical Toxicology, Vol. 82, No. S, …

WebApr 10, 2024 · The global Linalool market size was valued at USD 266.66 million in 2024 and is expected to expand at a CAGR of 4.51% during the forecast period, reaching USD 347.49 million by 2027. The report ... WebMar 1, 2008 · On the basis of these data, the maternal no observed adverse effect level (NOAEL) of linalool is 500 mg/kg/day, whereas the developmental NOAEL is ≥ 1000 mg/kg/day. It is concluded that linalool is not a developmental toxicant in rats at maternal doses of up to 1000 mg/kg/day.

Weblinalool L. 2 515-69-5 Cabreuva oil Myrocarpus frondosus Fr. Allem 68188-03-4 D2.12 0.3 515-69-5 ... • The RIFM Safety Assessment on α-Bisabolol if available at the RIFM Safety Assessment Sheet ... • IDEA project (International Dialogue for the Evaluation of Allergens) Final Report on the QRA2: Skin Sensitisation Quantitative Risk ...

WebRIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0. / Api, A. M.; Belsito, D.; Bhatia, S. et al. In: Food and Chemical Toxicology, Vol. 97, … how to reset a digital bathroom scaleWebGenotoxicity:linalool(CAS#78-70-6);benzoicacid,2-amino-(CAS#118-92-3) b.RepeatedDoseToxicity:linalool(CAS#78-70-6)andbenzoic acid,2-amino-(CAS#118-92-3) … north carolina hummingbird seasonWebApr 5, 2024 · According to forecasts, the Linalool market size is expected to reach USD 323.1 by 2028, exhibiting an unexpected CAGR of 3.30% during the period from 2024 to 2028. Additionally, an extensive ... north carolina hunter edWebJul 1, 2003 · The principal toxic effects observed were hypermotility with ataxia followed by sedation or depression and dyspnea ( RIFM, 1992 ). The i.p. LD 50 in male albino mice of a solution of linalool in isotonic sodium chloride with Tween 80 added was reported to be 0.340 g/kg (95% C.I. 0.267–0.510 g/kg). Animals were dosed at levels of 0.075–0.8 g/kg. how to reset a digital thermometer how to reset a desktopWebRIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6 A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, J. Shen, T. W. Schultz, I. G. Sipes Show 2 others north carolina hummingbirdWebThe environmental endpoint was completed as described in the RIFM Framework along with data from the suitable read across analog linalyl cinnamate (CAS # 78-375). ... The … how to reset a dead ipad