Phenol genotoxicity

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August undefined, 2024

WebThe genotoxicity of PCP has been attributed to its two major quinoid metabolites: tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone (TCBQ). Although the redox cycling of PCP quinoid metabolites to generate reactive oxygen species is believed to play an important role, the exact molecular mechanism underlying PCP genotoxicity is not clear. WebGenotoxicity associated with haem, N-nitroso compounds, and heterocyclic amines has been proposed as a mechanism underpinning this association. Citation 7 Amongst …

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WebIntegrated Risk Information System US EPA WebPhenol, 2-amino-5-methyl-: Human health tier II assessment 26 October 2024 C A S N u m b e r : 2 8 3 5 - 9 8 - 5 Preface This assessment was carried out by staff of the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) using the Inventory Multi-tiered Assessment and Prioritisation (IMAP) framework. sporting goods store bethesda

In silico genotoxicity of coumarins: application of the Phenol …

Web6. máj 2010 · Safety Assessment of Genotoxicity Potential of Impurities with Known Structure • Review all available information • Material Safety Data Sheet • Literature review … Web1. jan 2005 · The form of the phenolic compound is also important, because phenolic compounds occur in food mainly as conjugated compounds and the substances occurring in plasma and tissues are mainly mammalian conjugates, except for certain isoflavones and flavonols. ... Differential modulation of the genotoxicity of food carcinogens by naturally … sporting goods store burlington nc

Integrated Risk Information System US EPA

PROPYLENE GLYCOL PHENYL ETHER CAS N°

Web4-Aminophenol is a building block used in organic chemistry. Prominently, it is the final intermediate in the industrial synthesis of paracetamol. Treating 4-aminophenol with acetic anhydride gives paracetamol: [8] [9] [10] It is a precursor to amodiaquine, mesalazine, AM404, parapropamol, B-86810 & B-87836 (c.f. WO 2001042204 ). WebSubstances identified as endocrine disruptors at EU level This list contains substances that have undergone an evaluation of endocrine disrupting properties, as regulated in the EU in PPPR, BPR or REACH, and which are identified and legally adopted as endocrine disruptors. shelly beach golf club loginWebThere were 13 kinds of phenols were detected in the semi-coking wastewater, and the total mass concentration of them was 3 350 mg/L,and more than 90% of which were removed by physicochemical pretreatment. After both the biochemical and advanced treatment, phenols were almost not detected. sporting goods store bloomington il

"WebICH guideline Q3C (R6) on impurities: guideline for residual solvents EMA/CHMP/ICH/82260/2006 Page 2/39 Document History Code History Date " - Phenol genotoxicity

Phenol genotoxicity

WebAcquainted with techniques of Toxicology (Genotoxicity – Chromosomal aberration, immunomodulatory, nephrotoxicty, hepatotoxicity, in vivo oxidative stress). ... (Phaseolus vulgaris L.) is a source of nutrients and contains phenolic compounds having antioxidant activity and its consumption has been linked with improved health benefits. The ... Web12. apr 2024 · This study aims to select fungi isolates to reduce olive mill wastewater (OMWW) chemical oxygen demand (COD) and phenolic compounds (PC), as well as their …

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WebIt could be concluded that the comet assay is a sensitive and easy method to screen these chemicals and deserves further exploitation. Phenol and cresols are common toxic environmental pollutants. In this study, the micronucleus assay and the alkaline single cell gel electrophoresis (SCGE) technique have been used to investigate the genotoxic activity … Web7. okt 2024 · In the present study, it was aimed to determine the antigenotoxic activity of white tea against the genotoxic effect caused by two different alkylating antineoplastic cancer drugs streptozotocin (STZ) and cyclophosphamide (CP) in Drosophila melanogaster through the somatic mutation and recombination test (SMART). During the application of …

Web15. aug 2024 · Overall, the toxicity of phenol and the isomers of cresol was at similar level in terms of effect on aquatic lifeforms. Collectively, 91 ecotoxicological species were … WebThe genotoxicity of phenol has been extensively studied, especially from the perspective of it being a benzene metabolite. There is general agreement on the overall lack of mutagenicity of phenol tested in bacterial systems (IARC, 1999), although sporadic positive results in non-conventional bacterial assays (Gocke et al., 1981) and at

WebGenotoxicity and cytotoxicity of sevoflurane in two human cell lines in vitro with ionizing radiation ... The culture medium was changed every 2 days or when acidification was indicated by the pH indicator (phenol red). After irradiation, all microplates were incubated for an additional 24, 48 and 72 h, and no medium changes were performed. ... Web1-chloro-2,3-epoxypropane and phenol 9003-36-5 10 - 20 1,4-bis(2,3-epoxypropoxy)butane 2425-79-8 2.5 - 3 ... oligomeric reaction products with 1-chloro-2,3-epoxypropane and phenol: Genotoxicity in vitro : Metabolic activation: with and without metabolic activation : SAFETY DATA SHEET ARALDITE® 2014-2 RESIN Version 1.0 Revision Date:

WebNiclosamide is an oral anthelmintic drug, approved for use against tapeworm infections. Recent studies suggest however that niclosamide may have broader clinical applications in cancers, spurring increased interest in the functions and mechanisms of niclosamide. Previously, we reported that niclosamide targets a metabolic vulnerability in p53-deficient …

WebEach mL of the 1 mg/mL strength contains neostigmine methylsulfate 1 mg, phenol 4.5 mg (used as preservative), and sodium acetate trihydrate 0.2 mg, in water for injection. The pH is adjusted, when necessary, with acetic acid/sodium hydroxide to achieve a value of 5.5. ... Genotoxicity: Neostigmine methylsulfate was not mutagenic or clastogenic ... shelly beach day clinicWebPhenol, CAS No 108-95-2, food contact materials, hazard characterisation, TDI, toxicity, dose-response On request from Federal Institute for Risk Assessment (BfR) Question … sporting goods store cdaresearch article on phenol genotoxicity was retrieved, while no new publications on general toxicity were found. Concerning genotoxicity, phenol showed DNA-damaging activity in tests in vitro in yeast and mammalian cells. In studies in vivo with oral administration, phenol was negative in tests for sporting goods store austinWeb1) Phenol is not considered to be a carcinogen in experimental animals after repeated oral exposure (compare also with EU-RAR, 2006). 2) In most studies in experimental animals … sporting goods store butler paWebGenotoxicity of Phenols. Genotoxicity is an overarching term and refers to processes that alter the structure, information content or segregation of DNA and which are not necessarily associated with mutagenicity. Such processes include unscheduled DNA synthesis (UDS), sister chromatid exchange (SCE), DNA strandbreaks, DNA adduct formation, and ... shelly beach coromandelWebChemical subclasses of simple coumarins and furocoumarins were classified as active (xanthotoxin, isopimpinellin, esculin, scopoletin, scopolin and bergapten). In silico genotoxicity was mainly predicted for coumarins found in beer, sherry, dried parsley, fresh parsley and raw celery stalks. sporting goods store birmingham alWebSCCNFP/0522/01, final OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING SALICYLIC ACID adopted by the SCCNFP during the 20th plenary meeting of 4 June 2002 shelly beach hospital address