Oxazaphosphorine

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August undefined, 2024

WebThe oxazaphosphorine cyclophosphamide is one of the most widely used drugs in cancer chemotherapy. It is also used as an immunosuppressive at lower doses. As with the other … WebThe oxazaphosphorines cyclophosphamide, ifosfamide and trofosfamide remain a clinically useful class of anticancer drugs with substantial antitumour activity against a variety of …

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WebBackground: Oxazaphosphorines (cyclophosphamide (CPA), ifosfamide (IFO)) are major alkylating agents of polychemotherapy protocols but limiting their toxicity and increasing … WebOxazaphosphorine resistance, together with dose-limiting toxicity (mainly neutropenia and neurotoxicity), significantly hinders chemotherapy in patients, and hence, there is … topinvest cea

Insights into Oxazaphosphorine Resistance and Possible …

WebApr 1, 2015 · For intermittent oxazaphosphorine therapy. Oral administration of 40% of the dosage of the oxazaphosphorine on a weight for weight basis rounded down to the … WebIf the oxazaphosphorine dose is adjusted, the mesna dose should also be modified to maintain the mesna-to-oxazaphosphorine drug ratio. IV Bolus: 20% of the oxazaphosphorine dose at 0 hr, 4 hrs and 8 hrs Oral: 20% IV at 0 hr, 40% p.o … WebPotential mechanisms for oxazaphosphorine resistance include decreased activation by cytochrome P450s (e.g. CYP3A4, CYP2C9 and CYP2B6), increased deactivation of the agents by deactivating enzymes such as aldehyde dehydrogenases (ALDHs), increased cellular thiol level, increased DNA repair capacity, and altered cellular apoptotic response … top invest assinatura

Oxazaphosphorine

WebCyclophosphamide monohydrate, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan. Empirical Formula (Hill Notation): C 7 H 15 Cl 2 N 2 O 2 P · H 2 O. CAS Number: 6055-19-2. Molecular Weight: 279.10. Beilstein: 4678992. MDL number: MFCD00149395. PubChem Substance ID: 329775031. NACRES: NA.24. … WebOxazaphosphorine metabolism and transport have a major impact on pharmacokinetic variability, pharmacokinetic-pharmacodynamic relationship, toxicity, resistance, and drug …

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WebCyclophosphamide monohydrate. undefined. Synonyms: 2-[Bis(2-chloroethyl)amino]tetrahydro-2 H -1,3,2-oxazaphosphorine 2-oxide, Cytoxan. CAS 6055-19-2. Molecular Weight 279.10. Browse Cyclophosphamide monohydrate … WebNov 10, 2024 · Mesna (sodium 2-mercaptoethane sulfonate) is a detoxifying agent used to prevent hemorrhagic cystitis in patients receiving chemotherapy with either high-dose cyclophosphamide or ifosfamide.

WebMar 1, 2024 · Goethe-Universität Frankfurt am Main Abstract and Figures On the basis of the discovery that the proapoptotic aldehyde 3-hydroxypropanal is a cyclophosphamide metabolite, a novel mechanism of... WebThe oxazaphosphorines including cyclophosphamide (CPA), ifosfamide (IFO), and trofosfamide represent an important group of therapeutic agents due to their substantial antitumor and immuno-modulating activity.

WebJan 30, 2009 · P-Stereogenic oxazaphosphorine compounds of the form 4 have not previously been reported as asymmetric ligands for metal-catalyzed reactions. In an effort to explore the behavior of such oxazaphosphorine ligands, monomeric oxazaphosphorine borane 9 and dimeric oxazaphosphorine boranes 25 and 26 were synthesized as catalyst … WebBackground: Oxazaphosphorines (cyclophosphamide (CPA), ifosfamide (IFO)) are major alkylating agents of polychemotherapy protocols but limiting their toxicity and increasing their efficacy could be of major interest. Oxazaphosphorines are prodrugs that require an activation by cytochrome P450 (CYP).

WebOxazaphosphorine C3H4NOP CID 22137869 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and …

WebApr 1, 1994 · These observations demonstrate that ligands for the Ah receptor can induce a transient, largely oxazaphosphorine-specific, acquired cellular resistance, and they are consistent with the notion that elevated levels of a cytosolic class-3 aldehyde dehydrogenase nearly identical to the prototypical type-1 class-3 aldehyde dehydrogenase … top investigative moviesWebOxazaphosphorine metabolism and transport have a major impact on pharmacokinetic variability, pharmacokinetic-pharmacodynamic relationship, toxicity, resistance, and drug … top inverter batteryWebCyclophosphamide Synonyms: Cyclophosphamide monohydrate, 2- [Bis (2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan Empirical Formula (Hill Notation): C7H15Cl2N2O2P · H2O CAS Number: 6055-19-2 Molecular Weight: 279.10 Product Comparison Guide Use the product attributes below to configure the … top invest febrabanWebImportance of the field: The oxazaphosphorines (cyclophosphamide, ifosfamide and trofosfamide) are widely used in clinical practice for their antitumor and … top investable ai companiesWebIntratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy. In: Walden, P., Trefzer, U., Sterry, W., … pictures of sandringham house insideWebthe failed attempt to improve oxazaphosphorine cytostatics (OX) is the development of Glufosfamide ( -D-glucose-isophosphoreamide mustard), which has been synthesized on the basis of the rationale top invest exerciciosWebThe oxazaphosphorine cyclophosphamide is one of the most widely used drugs in cancer chemotherapy. It is also used as an immunosuppressive at lower doses. As with the other anticancer drugs discussed in previous sessions, it is a prodrug. top investigative stories