WebMonoclonal Antibody for studying YT521. Cited in 4 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, YTHDC1 … WebApr 4, 2024 · The YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m(6)A-YTH binding but also explain the preferential recognition of the GG(m(6)A)C sequences by YTHDC1. Hypoxia induces a specific switch in YT521 expression pattern towards the two non-protein coding mRNA variants, the already …
N6-methyladenosine reader protein YTHDC1 regulates …
WebYTHDC1 deficiency also resulted in the decrease of cardiomyocyte contractility and disordered sarcomere arrangement. By means of integrating multiple high-throughput … WebMay 2, 2024 · Chen et al. found that YTHDC1 was the essential m 6 A reader in acute myeloid leukemia and YTHDC1 was required to form nuclear YTHDC1-m 6 A condensates which help YTHDC1 to protect m 6 A-mRNAs ... phobia of words spelt the same way backwards
Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy
WebJan 1, 2024 · The approval number is IACUC-2024001. The Ythdc1 flox/flox mice were provided by the Cambridge-suda Genomic Resource Center. The exons 5–7 of the Ythdc1 gene were flanked by two loxp sites. Ythdc1 flox/flox mice were crossed with ... YTHDC1 (77422S, CST, 1:2000 dilution); β-actin (60008-1-lg, Proteintech, 1:5000 dilution) and … WebMay 21, 2024 · YTHDC1 recruits the serine and arginine-rich splicing factor 3 (SRSF3), restricts exon-skipping factor SRSF10 binding, and promotes exon inclusion . YTHDC1 also plays a key role in the processing of pre-mRNA in the nucleus of oocytes by interacting with the pre-mRNA 3′-end processing factors CPSF6, SRSF3, and SRSF7 . WebApr 1, 2024 · YTHDC1 (also known as YT521-B) was first identified as a protein that interacts with splicing factors that modulate RNA splicing [3, 8., 9., 10.It localises within the nucleus as puncta termed YT bodies, which are transcriptional active sites associated with RNA processing speckles [8., 9., 10.YTHDC1 consists of a YTH domain that is flanked … phobia of wobbly teeth